In addition, they show that the duration of the treatment determined the extent of the beneficial effects.

Cellular rejuvenation therapy safely reverses signs of aging in mice. Salk researchers treated mice with anti-aging regimen beginning in middle age and found no increase in cancer or other health problems later on.

When the researchers looked at normal signs of aging in the animals that had undergone the treatment, they found that the mice, in many ways, resembled younger animals. In both the kidneys and skin, the epigenetics of treated animals more closely resembled epigenetic patterns seen in younger animals. When injured, the skin cells of treated animals had a greater ability to proliferate and were less likely to form permanent scars—older animals usually show less skin cell proliferation and more scarring. Moreover, metabolic molecules in the blood of treated animals did not show normal age-related changes.